FRONTLINE Plus Flea and Tick Treatment for Medium Dogs (23–44 lbs) – 6 Doses

Protect your medium-sized dog with FRONTLINE Plus, the #1 trusted brand in flea and tick protection. Designed for dogs weighing 23 to 44 pounds, this fast-acting, long-lasting topical treatment kills fleas, ticks, and chewing lice while preventing future infestations. With just one easy monthly application, your dog stays protected for a full 30 days — even after bathing or swimming.

Advanced Dual-Action Formula

FRONTLINE Plus uses two proven active ingredients — Fipronil (9.8%) and (S)-Methoprene (8.8%) — to provide complete pest control. Fipronil kills adult fleas and ticks, while (S)-Methoprene prevents flea eggs and larvae from developing, breaking the flea life cycle and stopping re-infestations before they start.

Fast-Acting, Long-Lasting, and Waterproof

This waterproof formula begins working quickly to eliminate pests and keeps protecting your dog for a full month. Once applied, the treatment spreads through your pet’s natural oils and stores in the sebaceous glands, providing continuous release — even after exposure to water, rain, or bathing.

Easy Monthly Application

Applying FRONTLINE Plus is simple and stress-free:

1. Remove one applicator from the blister pack.

2. Open by snapping off the tip.

3. Apply directly onto your dog’s skin between the shoulder blades.

Use once every 30 days for consistent protection. Do not use on dogs under 8 weeks of age or weighing less than 23 lbs.

Key Benefits

• Kills fleas, flea eggs, and larvae to prevent re-infestations

• Eliminates ticks that can transmit Lyme disease

• Waterproof within 24 hours of application

• Safe and effective for dogs 8 weeks or older

• Vet-recommended and trusted by pet owners for over 20 years

Product Details

• Brand: Frontline

• Model: P004FLTSP6-23-44

• ASIN: B0002J1FNK

• Size: 6 Doses (6 Applicators)

• Weight: 1.6 oz

• Dimensions: 5.75 x 1 x 4.5 inches

• Color: Blue Box (for 23–44 lbs)

• Manufacturer: Boehringer Ingelheim Animal Health

• Country of Origin: United States

• Customer Rating: ★★★★☆ (4.4/5 stars, 23,000+ reviews)

Safety Information

• For external use only

• Do not use on puppies under 8 weeks or under 23 lbs

• Avoid contact with treated area until dry

• Do not allow ingestion of the product

• Individual sensitivities may occur; consult a veterinarian if irritation develops

Why Choose FRONTLINE Plus

• #1 veterinarian-recommended flea and tick brand¹

• Trusted by millions of pet owners for over 20 years²

• Provides complete, waterproof protection against fleas and ticks

• Simple once-a-month application for year-round peace of mind

Keep your dog healthy, happy, and itch-free with FRONTLINE Plus for Medium Dogs — the proven choice for fast, effective, and lasting protection.

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¹ Based on BI Marketing Excellence Survey, Kynetec, November 2023
² Supported by 20 years of independent studies and consumer trust research